Is there "new" monitoring available for children who get vigabatrin?
This time, I want to draw attention to a small study with the purpose of invastigating wether OCT (optical coherence tomography) can detect early vigabatrin-induced retinal toxicity in children.
You would need subscription of Elsevier or Sience Direct to be able to read the full-text-version. You can only find a link to the abstract here:
A few questions crossed my mind when I read the abstract:
You would need subscription of Elsevier or Sience Direct to be able to read the full-text-version. You can only find a link to the abstract here:
Optical coherence tomography to monitor vigabatrin toxicity in children
I don´t have the monetary power to buy all possibly interesting articles, so I can´t tell you more about the article then what is written in the abstract, and THAT one should read on its own (You don´t need me for that) . But the result was interesting: RNFL (retinal nerve fiber layer) thinning could be found in little children similar to those you find in adults taking vigabatrin and having restrictions in the visual field.
.) Can a study with much more patients confirm these results?
.) Should children getting vigabatrin be monitored with regular OCT?
.) If so, which intervals would make sense?
.) If so, which intervals would make sense?
.) And if you find RNFL thinning as described above in little children , would this lead to early support for training the visual sense?
I would be pleased if some experts could try to find answers to these questions.
I would be pleased if some experts could try to find answers to these questions.
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